Сlinical and Functional Significance of Ophthalmic Nutraceuticals in Elderly Patients at Different Stages of Age-related Macular Degeneration

Purpose. To evaluate the clinical and functional significance of the use of ophthalmic drugs in elderly patients at different stages of AMD development.
Patients and methods. The study included 23 patients (46 eyes; 65.8 ± 6.3 years; 5 men, 18 women) with “dry” (AREDS-2 and AREDS-3 categories) and “wet” (AREDS-4 category) forms of AMD, who took the vitamin and mineral complex with antioxidant and neuroprotective properties “Oftolik®” for a month (2 capsules daily with meals) in combination with a dietary supplement from sea urchin caviar “The power of the sea: longevity” (1 capsule 3 times a day with meals). Standard ophthalmological examination was performed; optical coherence tomography (OCT; OPTOPOL), computer perimetry (Octopus 600 Haag-Streit) took into account the presence of possible systemic side effects of exposure and the comfort of taking ophthalmic drugs. Effectiveness criteria: stabilization of AMD manifestations (based on OCT data), stabilization of corrected visual acuity (COC). Statistical analysis: arithmetic mean (M), standard deviation (σ), Me — median, lower (LQ) and upper (UQ) quartiles, Student’s t-test, W-Wilcoxon criterion, MannWhitney criterion.
Results. The use of the vitamin and mineral complex “Oftolik®” by AMD patients in combination with the dietary supplement from sea urchin caviar “Sea Power: longevity” helps to stabilize visual functions — visual acuity, ophthalmotonus, improve the functional state of the retina (reduce visual field defects, improve photosensitivity) and is accompanied by an increase in the total activity of antioxidant systems of blood plasma, normalization increased levels of lipid and carbohydrate metabolism. The level of proinflammatory cytokines in the blood serum of patients with the “dry” form of AMD is not a significant diagnostic feature. VEGF concentration can be used in clinical laboratory diagnostics as an additional diagnostic marker of the severity and prognosis of the disease course. Conclusion. The use of the vitamin and mineral complex “Oftolik®” in combination with the dietary supplement from sea urchin caviar “Sea Power: longevity” helps to stabilize visual functions and improve the functional state of the retina of patients with AMD.

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