Preview

Ophthalmology in Russia

Advanced search

Primary non-Hodgkins lymphoma of eye and adnexa. Effect of method of treatment for prognosis

https://doi.org/10.18008/1816-5095-2013-1-41-46

Abstract

Purpose: To identify predictors of NHL of the vision associated with treatment choice for prognosis of primary non-Hodgkin’s lymphoma eye and adnexa.


Methods: A retrospective and prospective study characteristics of the disease in 94 patients with primary lymphoma of the vision. Orbital lymphoma diagnosed in 35 patients (36 %), conjunctival — in 48 patients (52 %), the least damage observed age — 11 patients (12 %). Among the various types of malignant lymphomas morphologic immunological dominated B-cell lymphoma or marginal zone MALT-lymphoma, which were diagnosed in 70 (75 %). Patients were treated with radiation, chemotherapy and combined chemoradiotherapy.


Results: During the follow-up period of 1 year to 26 years (median follow-up 5 years) of the 94 patients the primary lymphoma of the vision in 22 cases (23 %) relapses occurred in a period of 6 months to 10 years (median 2 years). In analyzing the data we found that the 5‑year disease-free survival with radiation therapy, chemotherapy, and combination therapy is the same and is equal to — 70 %.


Conclusion: The treatment and monitoring of patients with primary non-Hodgkin’s lymphoma eye and adnexa should be implemented jointly ophthalmologist and oncology. The choice of treatment, with adequate treatment is prescribed, can not be associated with the weather and can not be a predictor of the primary non-Hodgkin’s lymphoma eye and adnexa.

About the Authors

E. E. Grishina
Офтальмологическая клиническая больница Департамента здравоохранения г. Москвы ГБОУ ДПО РМАПО Министерства здравоохранения России
Russian Federation


E. S. Guzenko
Офтальмологическая клиническая больница Департамента здравоохранения г. Москвы
Russian Federation


References

1. Бровкина А. Ф. Болезни орбиты // Руководство для врачей. — М.: Медицинское информационное агентство, 2008. С. 66‑70,159‑186, 190‑191, 192‑198. // Болезни орбиты. — М.: Медицина, 1993. С. 60‑66.

2. Волкова М. А. Комментарий 1. И. В. Поддубная. // Клиническая онкогематология. М., Медицина, 2007. С. 724‑766.

3. Гришина Е. Е. Злокачественные лимфомы. Диагностика и лечение с позиции офтальмолога // Клиническая офтальмология. 2006. Т. 7. № 1. С. 14‑16.

4. Гришина Е. Е. Неходжкинские лимфомы органа зрения. Лекция. М., 2007. С. 8‑14; 14‑16.

5. Гришина Е. Е. Патогенез внутриглазной лимфомы: В сб. научных трудов научно-практ. конф. «Опухоли и опухолеподобные заболевания органа зрения». 2010. С. 31‑35.

6. Красильникова Б. Б. Первичные лимфатические опухоли орбиты и придаточного аппарата глаза // Дис… канд. мед. наук. М., 2009. 60 с.

7. Поддубная И. В. Неходжкинские лимфомы. Лекция. М., 2012.

8. Поддубная И. В., Пробатова Н. А., Ковригина А. М. и др. Первичные MALT-лимфомы желудка различной степени злокачественности: проблемы диагностики и тактики лечения // Современная онкология. 1999. Т. 1. № 1. С.28‑36.

9. Bairey O., Kremer I., Rakowsky E., et al. Orbital and adnexal involvement in systemic non-Hodgkin’s lymphoma // Cancer. 1994. V. 73. P. 2395‑2423.

10. Belhadji M., Montaouakil A., Ladnass K., et al. Malignant non — Hodgkin’slymphoma in choroid and nasopharyngeal sites // J. Fr. Opthalmol. 1997. V. 20. P. 548‑550.

11. Cahill M., Barnes C., Moriarty P. et al Ocular adnexal lymphoma- comparison of I MALT lymphoma with other histological types // Br. J. Ophthalmol. 1999. V. 83 P. 742‑747.

12. Coupland SE, White VA, Rootman J, Damato B, Finger PT. A TNM-based clinical staging system of ocular adnexal lymphomas // ISOO MEETING 2009. P. 338.

13. Harris N., Jaffe E., Stein H., et al. A Revised European-American Classification of lymphoid neoplasms // Blood. 1994. V. 84. P. 1361‑1392.

14. Jaffe E. S. The 2008 WHO classification of lymphomas: implications for clinical practice and translational research. Hematology Am Soc Hematol Educ Program. 2009. P. 523‑531.

15. Jensen O. A., Johansen S., Kiss K. Intraocular T-cell lymphoma mimicking a ring melanoma. First manifestation of systemic disease. Report of a case and survey of the literature // Graefes Arch. Clin. Exp. Ophthalmol. 1994. V. 232. P. 148‑152.

16. Khalil H. A., de-Keiser R. J., Kluin P. M., et al. Clinical course and pathologic features of conjunctival non-Hodgkin’s lymphoma. A report of six cases // Graefes Arch. Clin. Exp. Ophthalmol. 1990. V. 228. P. 246‑251.

17. Kim KM, Yoon DH, Lee SG, et al. A case of primary adrenal diffuse large B-cell lymphoma achieving complete remission with rituximab-CHOP chemotherapy //J Korean Med Sci. 2009. V. 24. P. 525‑528.

18. Knowles D. M., Jacobiec F. A., McNally L., et al. Lymphoid hyperplasia and malignant lymphoma occurring in the ocular adnexa (orbit, conjimctiva, and eyelids): a prospective multiparametric analysis of 108 cases during 1977 to 1987. //

19. Hum. Pathol. 1990. V. 21. P. 959‑973.

20. Lagoo A. S., Hagerty C., Kim Y., et al. Morphologic features of 115 lymphomas of the orbit and ocular adnexa categorized according to the worldhealth organization classification // Arch. Pathol. Lab. Med. 2008. V. 132. P. 1405‑1416.

21. McKelvie P. A. Ocular adnexal lymphomas: a review // Adv Anat Pathol. 2010. V. 17. P. 251‑261.

22. McLean I. W., Burnier M. N., Zimmerman L. E., et al. Tumor of orbit. In: Rosai J., Sobin L. H. (eds). Atlas of tumor pathology: tumors of the eye and adnexa, ser 3, fasc 12 Washington: Armed Forces Institute of Pathology, 1993. P. 233‑298.

23. Medeiros L. J., Harmon D. C., Linggood R. M., et al. Immunohistologic featurs predict clinical behavior of orbital and conjunctival lymphoid infiltrates // Blood. 1989. V. 74. P. 2121‑2129.

24. Meunier J., Lumbroso-Le Rouic L., Dendale R., et al. Conjunctival low-grade non-Hodgkin’s lymphoma: a large single-center study of initial characteristics, natural history and prognostic factors // Leukemia & Lymphoma. 2006. — V. 47. P.1295‑1305.


Review

For citations:


Grishina E.E., Guzenko E.S. Primary non-Hodgkins lymphoma of eye and adnexa. Effect of method of treatment for prognosis. Ophthalmology in Russia. 2013;10(1):41-46. (In Russ.) https://doi.org/10.18008/1816-5095-2013-1-41-46

Views: 1107


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1816-5095 (Print)
ISSN 2500-0845 (Online)