Сlinical, functional and morphological results of diabetic macular edema antiangiogenic treatment in patients with diabetes mellitus type two
https://doi.org/10.18008/1816-5095-2013-1-50-55
Abstract
Purpose: To evaluate of retinal morphology and function progress in patients with diabetes type 2 and DME consistent with the level of pathogenetic factor in tear fluid.
Methods: The progress of visual acuity, retinal thickness and photosensitivity after ranibizumab intravitreal injection has been assessed.
Results: Statistically significant increase in visual acuity, retinal photosensitivity, decrease of retinal thickness and VEGF A level was found in the tear fluid after injection. The correlation of VEGF level in tear fluid with visual acuity after procedure was found to be negative.
Conclusion: Ranibizumab intravitreal injection is a pathogenic treatment leading to morphological and functional retinal state improvement.
About the Authors
L. K. MoshetovaRussian Federation
I. V. Vorobieva
Russian Federation
E. V. Parfenova
Russian Federation
D. A. Merkushenkova
Russian Federation
P. I. Makarevich
Russian Federation
V. I. Alekhnovich
Russian Federation
References
1. Аметов А. С. Сахарный диабет 2 типа. Проблемы и решения. М., 2011. ГЭО-ТАР-Медия. 720 с.
2. Нероев В. В., Сарыгина О. И., Левкина О. А. Роль сосудистого эндотелиального фактора роста в патогенезе диабетической ретинопатии // Вестн. офтальмол. 2009. № 2. С. 58‑60.
3. Парфенова Е. В., Плеханова О. С., Меньшиков М. Ю. и др. Регуляция роста и ремоделирования кровеносных сосудов: уникальная роль урокиназы // Рос. физиол. журн. им. И. М. Сеченова. 2009. Т. 95, № 5. С. 442464.
Review
For citations:
Moshetova L.K., Vorobieva I.V., Parfenova E.V., Merkushenkova D.A., Makarevich P.I., Alekhnovich V.I. Сlinical, functional and morphological results of diabetic macular edema antiangiogenic treatment in patients with diabetes mellitus type two. Ophthalmology in Russia. 2013;10(1):50-55. (In Russ.) https://doi.org/10.18008/1816-5095-2013-1-50-55