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The results of comparative analysis of angiogenic and laser therapy for diabetic macular edema in diabetes type 2

https://doi.org/10.18008/1816-5095-2013-2-44-49

Abstract

Purpose: To compare the results of laser treatment and intravitreal ranibizumab injections in patients with DME consistent with the level of VEGF A in tear fluid.


Methods: The progress of visual acuity, retinal thickness and light sensivity after laser treatment and ranibizumab intravitreal injection has been assessed.


Results: One month after the treatment the main effect of laser was the decrease of retinal thickness, whereas after ranibizumab — the increase of visual acuity. The significant decrease of VEGF A level in tear fluid was found only in ranibizumab group.


Conclusion: Laser treatment of DME leads to permanent retinal thickness decrease and insignificant functional improvement in comparison with ranibizumab IV injection, which leads to temporary morphological and functional improvement.

About the Authors

I. V. Vorobieva
ГБОУ ДПО РМАПО Минздрава России
Russian Federation


E. V. Parfenova
ГБОУ ДПО РМАПО Минздрава России
Russian Federation


D. A. Merkushenkova
ФГБОУ ВПО МГУ им. М. В. Ломоносова
Russian Federation


P. I. Makarevich
ФГБОУ ВПО МГУ им. М. В. Ломоносова
Russian Federation


V. I. Alekhnovich
ФГБОУ ВПО МГТУ им. Н. Э. Баумана
Russian Federation


References

1. Балашевич Л. И. Глазные проявления диабета. СПб: Издательский дом СПбМАПО, 2004. 453 с.

2. Нероев В. В. Современные аспекты лечения диабетического макулярного отека // Рос. офтальмол. журнал. 2012. № 1. С. 27‑30.

3. Шадричев Ф. Е. Диабетическая ретинопатия // Современная оптометрия. 2008. № 4. С. 36‑42.

4. Шадричев Ф. Е., Шкляров Е. Б., Григорьева Н. Н. Использование анти-VEGF терапии в лечении диабетического макулярного отека // Офтальмол. ведомости. 2011. № 4. С. 83‑92.

5. ETDRS Research Group. Photocoagulation for diabetic macular edema: Early Treatment Diabetic Retinopathy Study report number 1 // Arch Ophthalmol. 1985. V. 103. P. 1796‑806.

6. Mitchell P. on behalf of the Restore study group. Ranibizumab alone or adjunctive to laser vs. laser monotherapy in diabetic macular edema: twelve-month results of the RESTORE study // AAO. 2010. PA026.

7. Mitchell P., Bandello F., Schmidt-Erfurth U., et al. Ranibizumab monotherapy or combined with laser versus laser monotherapy for diabetic macular edema (RESTORE study) // Ophthalmology. 2011. V. 118. P. 615‑625.

8. Aiello L. P., Edwards A. R., Beck R. W., et al. DRCR Net. Factors associated with improvement and worsening of visual acuity 2 years after focal / grid photocoagulation for diabetic macular edema // Ophthalmology. 2010. V. 117. P. 946‑53.


Review

For citations:


Vorobieva I.V., Parfenova E.V., Merkushenkova D.A., Makarevich P.I., Alekhnovich V.I. The results of comparative analysis of angiogenic and laser therapy for diabetic macular edema in diabetes type 2. Ophthalmology in Russia. 2013;10(2):44-49. (In Russ.) https://doi.org/10.18008/1816-5095-2013-2-44-49

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ISSN 1816-5095 (Print)
ISSN 2500-0845 (Online)