The role of hormonal imbalance in the development of autoimmune dacryoadenitis in endocrine orbitopathy
https://doi.org/10.18008/1816-5095-2013-2-58-60
Abstract
The authors analyzed the hormonal profile of patients with Graves’ disease and endocrine orbitopathy with or without autoimmune dacryoadenitis. Presented compelling evidence about the role of hormonal imbalance between thyreoglobulines and thyroidstimulating hormones in the development of autoimmune dacryoadenitis. The availability of this kind of imbalance increases the risk of involvement of lacrimal gland in the pathological process with 12.3 % up to 64.3 % in the population with Graves’ disease and endocrine orbitopathy.
About the Authors
V. G. LikhvantsevaRussian Federation
T. N. Safonova
Russian Federation
O. A. Gontyurova
Russian Federation
E. A. Rudenko
Russian Federation
V. A. Vygodin
Russian Federation
References
1. Бровкина А. Ф. Эндокринная офтальмопатия. Издательский дом «ГэотарМед.» — М., 2004. С. 176
2. Лихванцева В. Г. Сафонова Т. Н. Гонтюрова О. А и др. Рентгенологические особенности эндокринной офтлаьмопатии с вовлечением слезной железы //Офтальмология. 2012. Т. 9, № 3. С. 57‑61.
3. Ткачук В. А. Введение в молекулярную эндокринологию. Учеб. пособие.…Издательство Московского университета. М., 1998. С. 256.
4. Azzarolo A. M., Wood R. L., Mircheff A. K., et al. Androgen influence on lacrimal gland apoptosis, necrosis, and lymphocytic infiltration // Invest Ophthalmol Vis Sci. 1999. V. 40. P. 592‑602.
5. Azarolo A. M., Mircheff A. K., Kaswa T. L. Androgen support of lacrimal gland function // Endocrine. 1997. V. 6. P. 39‑45.
6. Azzarolo A. M., Eihausen H., Schechter J. Estrogen prevention of lacrimal gland cell death and lymphocytic infiltration // Exp Eye Res. 2003. V. 77. P. 347‑354.
7. Sullivan D. A. Sex hormones and Sjogren’s syndrome // J Rheumatol. 1997. V. 24 (Suppl 50). P. 17‑32.
8. Sullivan D. A., Krenzer K. L., Sullivan B. D., et al. Does androgen insufficiency cause lacrimal gland inflammation and aqueous tear deficiency? // Invest Ophthalmol Vis Sci. 1999. V. 40. P. 1261‑1265.
9. Sullivan D. A., Belanger A., Cermak J. M. Are women with Sjogren’s syndrome androgendeficient? // J Rheumatol. 2003. V. 30. P. 2413‑2419.
Review
For citations:
Likhvantseva V.G., Safonova T.N., Gontyurova O.A., Rudenko E.A., Vygodin V.A. The role of hormonal imbalance in the development of autoimmune dacryoadenitis in endocrine orbitopathy. Ophthalmology in Russia. 2013;10(2):58-60. (In Russ.) https://doi.org/10.18008/1816-5095-2013-2-58-60