Pathological changes in the retina of eyes rats with experimental 2 type diabetes mellitus and their correction by oral gels with biologically active substances

Purpose: To study of therapeutic and prophylactic action on the retina of rats with experimental diabetes mellitus type 2 (DM2) oral mucosal gels containing biologically active substances (BAS).

Methods: DM2 was induced by protamine method Ulyanov and Tarasova [2000]. As BAS used lysozyme, flour of grape leaves, the water extract of blueberries and quercetin. Mucosal gels containing active substances, applied to the mucous lining of the mouth for 2 weeks. The serum glucose concentration was performed and histological studies of the retina.

Results: Application mucosal gels reduces BAS 8‑22 % glucose (most with blueberry extract) and significantly improves retinal histology (vacuolar degeneration less pronounced ganglion cells, there are no structural changes in photoreceptor layer). Gels revealed more effective with containing extract of bilberry, grape flour and quercetin.

Conclusion: Oral mucosal application of gels containing active substances, have protection of retina in diabetes mellitus type 2.

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