Signicef® (levoflaxacin 0.5%) eye drops in clinical practice
https://doi.org/10.18008/1816-5095-2012-4-73-77
Abstract
Purpose: to evaluate the effect of levoflaxacin 0.5% eye drops/Signicef® (Promed Exports, India) for prevention of infectious complications following ocular traumas and intraocular surgery as well as infectious disorders treatment.
Methods: In retrospective analysis were included 102 cases of different ophthalmic pathologies following intraocular surgery, i.e., phacoemulsification (27 cases), extracapsular cataract extraction (40 cases), intravitreal injection/IVt of Lucentis (23 cases), abscess/phlegmon drainage (3 cases). Levofloxacin 0.5% (Signicef® Eye Drops) was prescribed according to a scheme before and following ocular surgery for prevention and treatment of infectious complications.
Results: No infectious complications following eye surgery or IVt were observed.
Conclusion: Signicef® use as antibacterial mono-medication is reasonable and sufficient for prevention of post-op infectious
complications as well as ocular traumas and infectious corneal disorders treatment.
About the Author
E. A. SpiridonovRussian Federation
References
1. Вохмяков А. В., Околов И. Н. и др. Выбор оптимального антибиотика для профилактики инфекционных осложнений в офтальмохирургии // Клиническая офтальмология. — 2007. — Т. 8, No 1. — С. 37‐40.
2. Воронцова Т. Н., Бржеский В. В., Михайлова М. В. Чувствительность и резистентность к антибактериальным препаратам микрофлоры конъюнктивальной полости у детей //Офтальмология. — 2012. — Т. 9, No 1. — С. 83‐91.
3. Майчук Ю. Ф. Перспектива применения хинолоновых антибиотиков в офтальмологической практике. Актуальные проблемы химиотерапии бактери- альных инфекций. — М., 1991. — С. 408.
4. Barry P., Behrens‐Baumann W., Pleyer U., Seal D. (Ed.). ESCRS guidelines on prevention, investigation and management of postoperative endophthalmitis. Ver- sion 2. — 2007. — 14 p.
5. Holland E. J. New Options for Preventing Infection // Ocular Surgery News. — Sept., 2002. — P. 5‐6.
6. Практическое руководство по антиинфекционной химиотерапии. Под ре- дакцией: Л. С. Страчунского, Ю. Б. Белоусова, С. Н. Козлова. Смоленск: МАК- МАХ, 2007.
7. Nicolau D. P. et al. Antibiotic kinetics and dynamics for the clinician // Med. Clin. North. Am. — 1995. — Vol. 79. — P. 477‐495.
8. Kim SY, Lim JA, Choi JS, et al. Comparison of antibiotic effect and cornea epithe- lial toxicity between levofloxacin and moxifloxacin in vitro // Cornea. — 2007. — Vol. 26. — P. 720‐725.
9. Padma Bezwada, Clark LA, Shneider S. et al. Intrinsic cytotoxic effects of fluoro- quinolones on human corneal keratocytes and endothelial cells // Curr. Med. Res. Opin. 2008. — Vol. 246. — P. 419‐424.
Review
For citations:
Spiridonov E.A. Signicef® (levoflaxacin 0.5%) eye drops in clinical practice. Ophthalmology in Russia. 2012;9(4):73-77. (In Russ.) https://doi.org/10.18008/1816-5095-2012-4-73-77