Dry eye syndrome in thyroid-associated ophthalmopathy
https://doi.org/10.18008/1816-5095-2014-4-26-31
Abstract
Purpose: The pathogenesis of keratoconjunctivitis sicca in patients with thyroid eye disease is presented. The influence of therapy by a HYLO-PARIN® on a condition of a tear film in patients with various forms of thyroid eye disease is assessed.
Methods: 34 eyes (17 patients) with thyroid eye disease were investigated. Dry eye evaluations included Shirmer and Jhones testing, tear film break-up time, corneal fluorescein staining. Patients were treated with HYLOPARIN ® (Ursapharm, Germany).
Results: Study showed that HYLO-PARIN® resulted in marked improvement as assessed by subjective complaints, Schirmer’s test, tear film break-up test.
Conclusion: HYLO-PARIN® provided relief from the signs
and symptoms of dry eye syndrome at patients with various forms of thyroid eye disease.
About the Authors
A. F. Brovkina
Department of Ophthalmology of Russian Medical Academy of Postgraduate Education, 125993, Barrikadnaya street, 2 / 1. Moscow, Russian Federation.
Russian Federation
Russian Federation
O. N. Steshenko
Department of Ophthalmology of Russian Medical Academy of Postgraduate Education, 125993, Barrikadnaya street, 2 / 1. Moscow, Russian Federation.
Russian Federation
Russian Federation
O. D. Zhukova
Department of Ophthalmology of Russian Medical Academy of Postgraduate Education, 125993, Barrikadnaya street, 2 / 1. Moscow, Russian Federation.
Russian Federation
Russian Federation
References
1. The definition and classification of dry eye disease: report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop (2007). The ocular surface. 2007; 5 (2): 75‑92.
2. Brzheskij V. V., Somov E. E. [Keratoconjunctival xerosis (diagnosis, clinical features, treatment)]. SPb.: Publishing. «Lefty. Saint Petersburg» 2003. (in Russ.).
3. Bartalena L., Baldeschi L., Dickinson A. J. et al. Consensus statement of the European Group on Graves’ orbitopathy (EUGOGO) on management of GO. Eur. J. Endocrinol. 2008;158: 273‑285.
4. Eckstein A. K., Finkenrath A., Heiligenhaus A., Renzing-Köhler K., Esser J., Krüger C., Quadbeck B., Steuhl K. P., Gieseler R. K. Dry eye syndrome in thyroidassociated ophthalmopathy: lacrimal expression of TSH receptor suggests involvement of TSHR-specific autoantibodies. ActaOphthalmol. Scand. 2004; 82 (3): 291‑297.
5. Scofield R. H., Bruner G. R., Harley J. B., Namjou B. Autoimmune thyroid disease is associated with a diagnosis of secondary Sjögren’s syndrome in familial systemic lupus. Ann. Rheum. Dis. 2007;66 (3): 410‑413.
6. Scheurer E. D., Harrison R. A., Lee A. R. Update on thyroid eye disease and management. Clinical Ophthalmology 2009;3: 543‑551.
7. Villani E., Viola F., Sala R., Salvi M., Mapelli C., Curro N., Vannucchi G., Beck-Peccoz P., Ratiglia R. Corneal Involvement in Graves’ Orbitopathy: An In Vivo Confocal Study. Inv.Ophthalmol.Vis.Sci. 2010; 51 (9):4574‑8.
8. Brovkina A. F., Astahov Ju. S. [Manual of Clinical Ophthalmology]. Rukovodstvo po klinicheskoj oftal’mologii. Moscow.: Univ. «MIA», 2014. — 960 р. (in Russ.).
Review
For citations:
Brovkina A.F., Steshenko O.N., Zhukova O.D. Dry eye syndrome in thyroid-associated ophthalmopathy. Ophthalmology in Russia. 2014;11(4):26-31. https://doi.org/10.18008/1816-5095-2014-4-26-31
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