Autologous Serum and Recombinant Nerve Growth Factor in the Complex Treatment of Neurotrophic Keratitis
https://doi.org/10.18008/1816-5095-2024-4-777-785
Abstract
Neurotrophic keratitis is a frequent complication of neurosurgical interventions caused by a loss of corneal sensitivity due to damage of the trigeminal nerve pathway. The article presents a clinical case of a successful treatment of a neurotrophic corneal ulcer developed after removal of a giant trigeminal neurinoma. Treatment with autologous serum instillations made it possible to achieve ulcer healing and unstable corneal epithelialization. Stable epithelialization was achieved after temporary replacement of the autologous serum topical application with recombinant human nerve growth factor. In addition to ulcer healing and complete corneal epithelialization, regeneration of nerve fibers was noted (according to cornea confocal microscopy data).
About the Authors
E. A. Kasparova
Krasnov Research Institute of Eye Diseases
Russian Federation
Russian Federation
Kasparova Evgeniya А., PhD, leading researcher of Pathology of Optical Media
of the Eye Department
Rossolimo str., 11A, B, Moscow, 119021
Z. V. Surnina
Krasnov Research Institute of Eye Diseases
Russian Federation
Russian Federation
Surnina Zoya V., MD, senior researcher at the Department of Pathology
of Optical Media of the Eye
Rossolimo str., 11A, B, Moscow, 119021
N. R. Marchenko
Krasnov Research Institute of Eye Diseases
Russian Federation
Russian Federation
Marchenko Nikolay R., PhD, researcher at the Department of Pathology
of Optical Media of the Eye
Rossolimo str., 11A, B, Moscow, 119021
L. S. Pateyuk
Krasnov Research Institute of Eye Diseases
Russian Federation
Russian Federation
Pateyuk Lyudmila S., PhD, senior researcher at the Department of Pathology
of Optical Media of the Eye
Rossolimo str., 11A, B, Moscow, 119021
V. D. Yartsev
Krasnov Research Institute of Eye Diseases
Russian Federation
Russian Federation
Yartsev Vasily D., PhD, leading researcher at the Department of Pathology
of the lacrimal tract
Rossolimo str., 11A, B, Moscow, 119021
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Review
For citations:
Kasparova E.A., Surnina Z.V., Marchenko N.R., Pateyuk L.S., Yartsev V.D. Autologous Serum and Recombinant Nerve Growth Factor in the Complex Treatment of Neurotrophic Keratitis. Ophthalmology in Russia. 2024;21(4):777-785. (In Russ.) https://doi.org/10.18008/1816-5095-2024-4-777-785
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