CLINICAL EVALUATION OF THE EFFECTIVENESS OF MEDICATIONS NEUROTRANSMITTER ACTIONS IN THE TREATMENT OF PATIENTS WITH PRIMARY GLAUCOMA

Aim was to study the effectiveness of neuromedin in the treatment of patients with primary glaucoma with compensated intraocular pressure (IOP). patients and methods. There were 40 patients (80 eyes): 10 eyes with early stage, 36 — advanced, 33 — advanced and 1 eye with end-stage glaucoma. IOP was offset by drops in the history of the 26 eyes underwent surgical treatment. Neuromedin was administered at 20 mg 2 times a day, 25 days. Efficacy was evaluated by visual status, fluid dynamics and morphometric parameters of the disk. results. Under the influence of neuromedin reduced the number of cattle and increased the number of zones with normal retinal sensitivity in the initial stage of 14.9%. In the advanced stage, the acuity improved to 66.6 per cent, in 33.3% of cases has not changed. In advanced stage, the visual acuity increased to 51.5% and 48.5% had not changed. In advanced stage, the effect is less pronounced: the number of livestock type 1 and 2 declined by 3.0±0.6 to 2.9±0.8% respectively, while the absolute number of livestock has not changed, the number of zones with normal sensitivity increased by 7.4±2,0%. Field of view is increased at all seeing eyes. Decreased true IOP, activation of the outflow chamber moisture. In initial and advanced stages significantly decreased the area of excavation, increased the area of the neuroretinal belt and the thickness of the retinal nerve fibers. In advanced stages it only changes the thickness of the retinal nerve fibers. More pronounced than in traditional therapy, the visual acuity improvement, the expansion of the field of view, the effect on retinal sensitivity and indicators HRT, probably due to a central action of neuromedin and activation of ganglion cells in a state of parabiosis. In recent years, in the literature there have been reports about the possible generality of the pathogenetic mechanisms of primary glaucoma and neurodegenerative diseases due to mitochondrial dysfunction, therefore, the positive dynamics of visual functions on the background of treatment with neuromedin can be explained by the ability of the drug to affect the energy potential of cells, to have a positive impact on cognitive function. Conclusion. Neuromedin has a positive impact on the state of visual functions, hydrodynamics and morphometric parameters of the disk.

1. Avdeev R.V., Aleksandrov A.S., Basinskij A.S., Bljum E.A., Brezhnev A.Ju., Volkov E.N., Gapon'ko O.V., Gorodnichij V.V., Gorshkova M.S., Dorofeev D.A., Zavadskij P.Ch., Zvereva O.G., Karimov U.R., Kulik A.V., Kuroedov A.V., Lanin S.N., Lovpache Dzh.N., Loskutov I.A., Molchanova E.V., Ogorodnikova V.Ju., Onufrijchuk O.N., Petrov S.Ju., Rozhko Ju.I., Sidenko T.A., Tazhibaev T.Dzh., Shepeleva A.V. [Clinical and epidemiological study of risk factors in the development and progression of glaucoma]. Kliniko jepidemiologicheskoe issledovanie faktorov riska razvitija i progressirovanija glaukomy. [Russian ophthalmological journal]. Rossijskij oſtal'mologicheskij zhurnal. 2013;3:9 16 (in Russ.).

2. Alekseev V.N., Gazizova I.R. [Neurodegenerative changes in patients with primary open angle glaucoma]. Nejrodegenerativnye izmenenija u bol'nyh pervichnoj otkrytougol'noj glaukomoj. [Practical medicine]. Prakticheskaja medicina. 2012;4:154 156 (in Russ.).

3. Zaharova I.A., Avdeev R.V., Pristavka V.A., Surnin S.N. [The influence of drugs neurotransmitter actions in the course of glaucoma process]. Vlijanie preparatov nejromediatornogo dejstvija na techenie glaukomnogo processa. Nacional'nyj zhurnal glaukoma. [National journal of glaucoma]. Nacional'nyj zhurnal glaukoma. 2014;4:40 47 (in Russ.).

4. Bakshinskij P.P., Vagin B.I., Budnik V.M., Doronina N.M. [The change of indicators of regional hemodynamics in patients with open angle glaucoma]. Izmenenie pokazatelej regional'noj gemodinamiki u bol'nyh otkrytougol'noj glaukomoj. [Annals of ophthalmology]. Vestnik oſtal'mologii. 1998;2:9 12 (in Russ.).

5. Flammer J. Glaucomatous optic neuropathy a Reperfusion injury. Klin-Monatsbl-Augenheilkd. 2001;290 291.

6. Flammer J., Orgiil S. Pathophysiology of optic nerve circulation in glaucoma. Vascular system of the optic nerve and perioptical area. 1998;243 258.

7. Alekseev V.N., Dzhan Shasha, Levko M.A. [Neuroprotection in POAG. Experimental and clinical study]. Nejroprotekcija pri POUG. Jeksperimental'no - klinicheskoe issledovanie. Glaukoma. [Glaucoma]. 2008;4:3 6 (in Russ.).

8. Nesterov A.P. [Glaucoma]. Glaukoma. Moscow, Medicina, 2008. (in Russ.).