The Fluorescein Angiographic Signs of Aggressive Posterior Retinopathy of Prematurity
https://doi.org/10.18008/1816-5095-2019-1S-61-67
Abstract
The purpose is to study the fluorescence angiographic signs of posterior aggressive retinopathy of prematurity. Patients and methods. A prospective study of 83 infants with aggressive posterior retinopathy of prematurity (APROP), who were on treatment in the neonatal center in 2012–2018 years. Gestational age was between 22 and 30 weeks. Depending on the diagnostic methods, patients were divided into two groups: 1 (main) — 51 (61.4 %) children who, in addition to standard ophthalmic examination methods, received 132 series of FA using a pediatric retinal camera RetCam3; 2 (control) — 32 (38.6 %) children without FA. After the procedure, the somatic state of the child was monitored for 24 hours for the registration of drug dye side effects. Results. Angiographic predictors of the disease and objective signs of APROP manifestation were presented in group 1 children a week earlier than in the group 2. This made laser treatment possible on 2.0 ± 0.5 weeks earlier in the group 1 (32.8 ± 1.2 weeks) compared to group 2 (34.8 ± 1.7 weeks) (p < 0.05) and to increase its efficiency by 8.2 % (86.3 and 78.1 % respectively). Conclusion. Comparative analysis of angiograms and color fundus images obtained with RetCam3 in the studied groups of children demonstrates the advantages and safety FA for the detection angiographic predictors of APROP, early objective signs of disease manifestation, it provides timely and effective laser treatment of complicated categories of very premature infants.
About the Authors
E. I. Saidasheva
North-Western State Medical University named after I.I. Mechnikov
Children’s Hospital No. 1
Russian Federation
Russian Federation
MD, PhD, professor of ophthalmology department
Kirochnaya St., 41, Saint Petersburg, Russia
Avangardnaya St., 14, Saint Petersburg, Russia
S. V. Buynovskaya
Children’s Hospital No. 1
Russian Federation
Russian Federation
ophthalmologist of neonatal department
Avangardnaya str., 14, Saint Petersburg, Russia
F. V. Kovshov
Children’s Hospital No. 1
Russian Federation
Russian Federation
ophthalmologist of neonatal department
Avangardnaya str., 14, Saint Petersburg, Russia
Yu. V. Levadnev
Children’s Hospital No. 1
Russian Federation
Russian Federation
PhD, anesthesiologist
Avangardnaya str., 14, Saint Petersburg, Russia
O. Y. Shishkanova
Children’s Hospital No. 1
Russian Federation
Russian Federation
anesthesiologist
Avangardnaya str., 14, Saint Petersburg, Russia
References
1. Federal clinical recommendations «Diagnostics, Monitoring and Treatment of Active Phase of Retinopathy of Prematurity» (The national protocol). Russian pediatric ophthalmology = Rossijskaja pediatricheskaja oftal’mologija. 2015;(1):54–60 (In Russ.).
2. Katargina L.A. Retinopathy of Prematurity, modern state of the problem and targets of the eye care organization to premature babies in the Russian Federation. Russian pediatric ophthalmology = Rossijskaja pediatricheskaja oftal’mologija. 2012;(1):5–7 (In Russ.).
3. Saidasheva E.I., Gorelik Y.V., Buyanovskaya S.V., Kovshov F.V. Retinopathy of prematurity: the course and results of treatment in children with gestational age less than 27 weeks. Russian pediatric ophthalmology = Rossijskaja pediatricheskaja oftal’mologija. 2015;(2):28–32 (In Russ.).
4. Saidasheva E.I., Lubimenko V.A., Buyanovskaya S.V., Kovshov F.V. The diagnostic significance of fluorescence angiography for the early detection and prognostication of the development of active retinopathy of prematurity in the infants born on the deadlines of gestation. Russian pediatric ophthalmology = Rossijskaja pediatricheskaja oftal’mologija. 2017;9(1):17–22 (In Russ.). DOI: 10.18821/1993-1859-2017-12-1-17-22
5. Heimann H., Kellner U., Foerster M. Atlas of Fundus Angiography. New York: Georg Thieme Verlag; 2006:13–20 (In Russ.).
6. Dithmar S., Holz F.G. Fluorescence Angiography in Ophthalmology. Heidelberg: Jumper publishing company medicine; 2008:126–130 (In Russ.).
7. Ng E., Lanigan B., O’Keefe M. Fundus Fluorescein Angiography in the screening for and management of Retinopathy of Prematurity. J. Pediatr. Ophthalmol. Strabismus. 2006;43(3): 85–90.
8. Azad R.1., Chandra P., Khan M.A., Darswal A. Role of intravenous fluorescein angiography in early detection and regression of retinopathy of prematurity. J. Pediatr. Ophthalmol. Strabismus. 2008;45(10):36–39.
9. Anselmetti G., Bianchi P.E., Giacosa E. Retinopathy of Prematurity. Atlas ophthalmoscopy and fluorescein angiography. 2008;27–29.
10. Yokoi T., Hiraoka M., Miyamoto M., Kobayashi Y., Nishina S., Azuma N. Vascular abnormalities in aggressive posterior retinopathy of prematurity detected by fluorescein angiography. Ophthalmology. 2009;(116):1377–1382. DOI: 10.1016/j.ophtha.2009.01.038
11. Lepore D., Molle F., Monica M., et al. Atlas of Fluorescein Angiographic Findings in Eyes Undergoing Laser for Retinopathy of Prematurity. Ophthalmology. 2011;118(1):168–175. DOI: 10.1016/j.ophtha.2010.04.021
12. Kogoleva L.V., Katargina L.A., Roudnitskaya Y.L. Macula structure and function in retinopathy of prematurity. Annals of Ophthalmology = Vestnik oftal’mologii. 2011;127(6):25–29 (In Russ.).
13. Saidasheva E.I., Buyanovskaya S.V., Kovshov F.V., Levadnev Y.V. The modern approaches to diagnosis and laser treatmentof aggressive posterior retinopathy of prematurity. Herald of the North-Western State Medical University named after I.I. Mechnikov = Vestnik Ssevero-Zapadnogo gosudarstvennogo meditsinskogo universiteta im. I.I. Mechnikova. 2017;9(1):42–47 (In Russ.).
14. Saidasheva E.I., Buyanovskaya S.V., Kovshov F.V. Fluorescent angiography as a method of optimizing a laser treatment of the aggressive posterior retinopathy of prematurity of the disabled. Modern technologies in ophthalmology = Sovremennye tehnologii v oftal’mologii. 2017;(1):255–258 (In Russ.).
15. Hittner H.M., Hirsch N.J., Rudolph A.J. Assessment of gestational age by examination of the anterior vascular capsule of the lens. J. Pediatr. 1977;(91):455.
Review
For citations:
Saidasheva E.I., Buynovskaya S.V., Kovshov F.V., Levadnev Yu.V., Shishkanova O.Y. The Fluorescein Angiographic Signs of Aggressive Posterior Retinopathy of Prematurity. Ophthalmology in Russia. 2019;16(1S):61-67. (In Russ.) https://doi.org/10.18008/1816-5095-2019-1S-61-67
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